Research

Pathophysiology

I use model systems and human postmortem tissue to probe mechanisms of neurodegeneration, elucidating connections between life-history factors and selective vulnerability.

biomarkers and therapeutics

Moving my study of selective vulnerability from bench to bedside, I seek to improve detection, risk-stratification, and treatment for neurodegeneration using novel technologies in highly cross-functional settings.

evolutionary medicine

The patterns and processes underlying evolutionary biology provide a useful framework to address the fundamental principles underlying complex diseases like Alzheimer’s.